| Acronym | Meaning |
 | LLT | Long Leadtime |
| LM | Information Memory |
| LM | Inner Maker |
| LM | Interface Module |
| LM | Intermediate Moisture |
| LM | Left Mid |
| LM | Long Module |
| LMCC | Integrated Mission Control Center |
| LME | Launch Monitor Equipment |
| LMF | Lower Mid-Fuselage |
| LMG | Left Main Gear |
| LMK | Landmark |
| LMP | List Of Measurement Points |
| LMS | Information Management System |
| LMS | Inventory Management System |
| LMS | Load Measurement System |
| LMS | Logistics Master Schedules |
| LMSC | Lockheed Missiles And Space Corporation |
| LN | Line |
| LN2 | Liquid Nitrogen |
| LNCH | Launch |
| LNDG | Landing |
| LNG | Liquefied Natural Gas |
| LO | Launch Operations |
| LO | Local Oscillator |
| LO | Lock-On |
| LO2 | Liquid Oxygen |
| LOA | Landing Operations Area |
| LOA | Launch Operations Area |
| LOAP | List Of Applicable Publications |
| LOB | Left Outboard |
| LOB | Line Of Balance |
| LOC | Launch Operations Complex |
| LOC | Localizer |
| LOC | Location |
| LOCC | Launch Operations Control Center |
| LOE | Left Outboard Elevon |
| LOE | Level Of Effort |
| LOE | Line Of Effort |
| LOFAR | Low Frequency Acquisition And Ranging |
| LOFO | Low Frequency Oscillation |
| LOGO | Limit Of Government Obligation |
| LOI | Lunar Orbit Insertion |
| LOL | Limit Of Liability |
| LOLI | Limited Operational-Life Items |
| LOM | Input/Output Module |
| LON | Longitude |
| LONG | Longitude |
| LOP | In-Orbit Plane |
| LOP | Input/Output Port |
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