| Acronym | Meaning |
 | HX | Heat Exchanger |
| HXIS | Hard X-ray Imaging Spectrometer |
| HYD | Hydraulic Subsystem |
| HYD | HYdraulics |
| HYDROGEN | Purge |
| HYDROGEN | ReHydrogen Relief |
| HYG | LHypergolic |
| HYPACE | Hybrid Programmable Attitude Control Electronics |
| HZ | Hertz (Cycles Per Second) |
| I | NTC/0INTC/0Integrated Checkout |
| I | LAS Instrument Landing Approach System |
| I | LSP IntegratedLogistics Support Plan |
| I | DAC Integrated Digital-Analog Converter |
| I | DAS Integrated Data Acquisition System |
| I | DPS Interface Digital Processor |
| I | ECM Induced Environment Contamination Monitor |
| I | ECO Inboard Engine Cutoff |
| I | LCCS Integrated Launch Control And Checkout System |
| I | D&CA Inverter Distribution And Control Assembly |
| I | FIntermediate Frequency |
| I-LOAD | Initial-load |
| I@@PL | Implement |
| IACS | Inertial Attitude Control System |
| IAD | Interface Agreement Document |
| IAD | Interface Analysis Document |
| IAL | Immediate Action Letter |
| IAL | International Algebraic Language |
| IARS | Independent Air Revitalization System |
| IAS | Impact Assessment Sheet |
| IAS | Indicated Airspeed |
| IAS | Integrated Avionics System |
| IASS | Inverter/ATCS Support Structure |
| IAT | Integrated Avionics Test |
| IAV | Inventory Adjustment Voucher |
| IB | Inboard |
| IB | Inert Building |
| IB | Instruction Book |
| IBF | Internally Blown Flap |
| IBM | International Business Machines |
| IC | Intercomputer Communication |
| IC/ES | Intercommunication/Emergency Station |
| ICA | Item Change Analysis |
| ICAO | International Civil Aviation Organization |
| ICAO | International Civil Aviation Organization |
| ICAR | Investigation And Corrective Action Report |
| ICB | Interim Change Bulletin |
| ICB | Interrupt Control Block |
| ICC | Intercomputer Channel |
| ICC | Intercomputer Communication |
| ICC | Interface Control Chart |
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