| Acronym | Meaning |
 | HE | Helium |
| HE | High Energy Astrophysics |
| HEAO | High Energy Astronomy Observatory |
| HEAP | High Energy Aim Point |
| HECV | Helium Check Valve |
| HEG | Helium Gage |
| HEGV | Helium Gage Valve |
| HEM | Hitchhike Experiment Module |
| HEMI | Hemispherical (S-Band Antenna) |
| HEMV | Helium Manual Valve |
| HEO | High Energy Orbit |
| HER | HIM EquiPment Rack |
| HERSCP | Hazardous Exposure Reduction And Safety Criteria Plan |
| HESS | High Energy Squib Simulator |
| HETM | Hybrid Engineering Test Model |
| HEX | Heat Exchanger |
| HEX | Hexadecimal |
| HEX | Hexagon |
| HF | Hard Failure |
| HF | High Frequency |
| HF | Horizontal Flight |
| HF | Hot Firing |
| HF | Hydrogen Fill |
| HF | Hyperfiltration |
| HFA | High Frequency Accelerometer |
| HFC | Heat Flow And Convection |
| HFC | Hydraulic Flight Control |
| HFCT | Hydraulic Flight Control Test |
| HFCV | Helium Flow Control Valve |
| HFDS | Hydrogen Fluid Distribution System |
| HFE | High Frequency Executive |
| HFM | Hollow Fiber Membrane |
| HFMU | High Fidelity Mockup |
| HFO | High Frequency Oscillator |
| HFS | Horizontal Flight Simulator |
| HFT | Horizontal Flight Test |
| HFTF | Horizontal Flight Test Facility |
| HFTS | Horizontal Flight Test Simulator |
| HFX | High Frequency Transceiver |
| HG | High Gain |
| HG | Mercury |
| HGA | High Gain Antenna |
| HGDS | Hazardous Gas Detection System |
| HGM | Hot-Gas Manifold |
| HGR | Hangar |
| HGR&SPTFAC | Hangar And Support Facility |
| HGS | Hydrogen Gas Saver |
| HGV | Hydrogen Gas Valve |
| HGVT | Horizontal Ground Vibration Test |
| HHC | Hammer Head Crane |
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