| Acronym | Meaning |
 | FLOT | Flotation |
| FLP | Flap |
| FLPS | Flight Load Preparation System |
| FLR | Failure |
| FLR | Flare |
| FLS | Flight Surgeon |
| FLSC | Flexible Linear Shaped Charge |
| FLT | Flight |
| FLT | Floating |
| FLTR | Filter |
| FLTSATCOM | Fleet Satellite Communications |
| FLUOR | Fluorescent |
| FLW | Fellows (TACAN Station) |
| FM | Frequency Modulation |
| FM | Flight Model |
| FM | Frequency Modulation (Modulated) |
| FM/FM | Frequency Modulation/Frequency Multiplexing |
| FM/PM | Frequency Modulation/Phase Modulation |
| FMA | Failure Mode Analysis |
| FMAHTS | Flight Manifest And Hardware Tracking System |
| FMANTS | Flight Manifest |
| FMC | Food Machinery Corporation |
| FMCF | First Manned Captive Flight |
| FMDM | Flex Multiplexer/Demultiplexer |
| FMEA | Failure Modes And Effects Analysis |
| FMEC | Forward Master Events Controller |
| FMECA | Failure Mode |
| FML | Fault Message Line |
| FML | Final Materials List |
| FMO | Flight Medical Officer |
| FMOF | First Manned Orbital Flight |
| FMOFEV | First Manned Orbital Flight With EVA |
| FMOFPL | First Manned Orbital Flight With Payload |
| FMR | Field Modification Request |
| FMR | Function Max Rate |
| FMS | Food Management System (Subsystem) |
| FMSP | FM Signal Processor |
| FMSP | Frequency Modulation Signal Processor |
| FMT | FlightManagementTeam |
| FMX | FM Transmitter |
| FND | Facility Need Date |
| FNL | Final |
| FNT | Failure Notification Telex |
| FO | Fail Operational |
| FO | Fiber Optics |
| FO | Objective |
| FO/FS | Fail-Operational/Fail-Safe |
| FOB | Flight Operations Building |
| FOB | Free On Board |
| FOC | Focus |
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