| Acronym | Meaning |
 | FF | Free Flight |
| FFBD | Functional Flow Block Diagram |
| FFC | Final Flight Certification |
| FFD | FixedFormatDisplay |
| FFD | Functional Flow Diagram |
| FFM | Free-Flying (Experiment) Module |
| FFP | Firmed Fixed Price |
| FFTO | Free-Flying Teleoperator |
| FH | Flex Hose |
| FHC | Flight Half Coupling |
| FHD | Fixed Head Disk |
| FHF | First Horizontal Flight |
| FHO | Failed Handover |
| FHP | Fuel High Pressure |
| FHS | Forward Heat Shield |
| FI | FlightInstrumentation |
| FI | Formal Inspection |
| FIAR | Failure Investigation Action Report |
| FID | Failure Identification |
| FID | Flight Implementation Directive |
| FIDO | Flight Dynamics Officer |
| FIE | Flight Instrumentation Engineer |
| FIFO | First In-First Out (High Speed Data Buffers) |
| FIG | Figure |
| FIIG | Federal Item Identification Guide |
| FIL | Filament |
| FILE | Future Identification And Location Experiment |
| FIO | Furnished And Installed By Others |
| FIR | Fuel Indicating Reading |
| FIS | Facility Interface Sheets |
| FIT | Fault Isolation Test |
| FITH | Fire-in-the-Hole |
| FIV | Fuel Isolation Valve |
| FKB | Flight Display Keyboard |
| FL | Fail |
| FL | Fault Identification |
| FL | Feed Lines |
| FL | Flowline |
| FL | Forward Link |
| FL | MECH Fluid Mechanical |
| FLAP | Flight Application Software |
| FLC | Federal Library Committee |
| FLC | Forward Load Control |
| FLCA | Forward Load Controller Assembly |
| FLD | Field |
| FLEX | Flexible |
| FLG | Flag |
| FLG | Flange |
| FLLK | Frustum Lifting Lug Kit |
| FLN | Fuel Line |
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