| Acronym | Meaning |
 | EOC | Engine-out Capability |
| EOD | Estimated OnDock |
| EOD | Explosive Ordnance Disposal |
| EODB | End Of Data Block |
| EOF | End Of File |
| EOG | Electroculogram |
| EOHT | External Oxygen And Hydrogen Tanks |
| EOI | Earth Orbit Insertion |
| EOL | End Of Line |
| EOM | End Of Message |
| EOM | End Of Mission |
| EOM | Engineering Operations Manual |
| EOM | Equations Of Motion |
| EOMF | End Of Minor Frame |
| EOP | Earth And Ocean Physics |
| EOP | Emergency Oxygen Pack |
| EOP | Experiments Of Opportunity |
| EOPAP | Earth And Ocean Physics Application Program |
| EOPO | Equal Opportunity Program Office |
| EOR | Earth Orbit Rendezvous |
| EOS | Earth Observation Satellite |
| EOS | Earth Orbit Shuttle |
| EOS | Emergency Oxygen Supply |
| EOS | Emergency Oxygen System |
| EOS | Extended Operating System |
| EOT | End Of Tape |
| EOT | End Of Transmission |
| EOW | Energy Over Weight |
| EP | Elbow Pitch |
| EP | Electrical Power |
| EP | Environmental Protective Plan |
| EPA | Environmental Protection Agency |
| EPC | Error Protection Code |
| EPC | External Power Contractor |
| EPCDC | Electrical Power Conditioning |
| EPCDC | Control |
| EPD | Electrical Power Distribution |
| EPD | Emergency Procedures Document |
| EPDB | Electrical Power Distribution Box |
| EPDB | Experiment Power Distribution Box |
| EPDC | Electrical Power Distribution And Control |
| EPDCS | Electrical Power Distribution And Control System |
| EPDS | Electrical Power And Distribution Subsystem |
| EPDS | Electrical Power Distribution Subsystem |
| EPDS | Electrical Power Distribution System |
| EPDU | Electrical Power Distribution Unit |
| EPG | Electrical Power Generator |
| EPL | Electronic |
| EPL | Electrical Power Level |
| EPL | Emergency Power Level |
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