| Acronym | Meaning |
 | DTPR | Detailed Test Procedures |
| DTRD | Development Test Requirements Document |
| DTS | Data Transfer System |
| DTS | Data Transmission System |
| DU | Display Unit |
| DU | Display Unit |
| DUA | Digital Uplink Assembly |
| DUC | Digital Uplink Command |
| DUM | Dummy |
| DUPLX | Duplex |
| DUPLXR | Duplexer |
| DUR | Duration |
| DV | Designated Verification |
| DV | Designee For Verification |
| DV | Differential Velocity |
| DVD | Delta Velocity Display |
| DVM | Digital Voltmeter |
| DVS | Design Verification Specification |
| DVS | Digital Voice System |
| DVT | Design Verification Testing |
| DW | Data Word |
| DWG | Drawing |
| DWI | Data Word In |
| DWS | Disaster Warning Satellite |
| DWV | Dielectric Withstanding Voltage |
| DY | Deputy Director (KSC Directorate) |
| DYN | Dynamic |
| E | East |
| E | LACS Extended Life Attitude Control System |
| E | LSCEarth Landing Sequence Controller |
| E | LSSEmergency Life Support System |
| E&D | Engineering And Development |
| E&D | Engineering And DeveloPment Directorate (JSC) |
| E-E | End-to-End |
| E-MUX | Electrical Multiplex |
| E-P | Electron/Proton |
| E/0-IMS | E/0-Information Management System |
| E/C | Encoder/Coupler |
| E/L | Entry/Landing |
| E/M | Engineering Model |
| E/O | Engineering/Operations |
| E/W | Energy Over Weight |
| E/W | Energy To Weight Ratio |
| EA | Each |
| EA | Electronic Assembly |
| EA | Elevation Angle |
| EAC | Energy Absorbing Capacity |
| EAC | Estimate At Completion |
| EAD | ElectricallY Alterable Device |
| EADI | Electronic Attitude Director Indicator |
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