| Acronym | Meaning |
 | DISTR | DITData Ld Table |
| DISTR | DIUDynamic Integrated Test |
| DISTR | DIVDivision |
| DK | Deck |
| DK | Display Keyboard |
| DK | DisplaY/Keyboard |
| DK | Docking |
| DL | DeveloPment-Left |
| DL | Downlink |
| DL | Electronics Engineering (KSC DE Dir.) |
| DLAT | Destructive Lot AccePtance Testing |
| DLC | Direct Lift Control |
| DLS | Dynamic Load Simulator |
| DLY | Delay |
| DM | Document |
| DM | Data Manager |
| DM | DeveloPment Motor |
| DM | DeveloPmental Instrumentation MDM.Mid |
| DM | Disassembly Manual |
| DM | Docking Mechanism |
| DMA | Direct MemorY Access |
| DMA | Direct MemorY Address |
| DMC | Data Management ComPuter |
| DMC | Direct Maintenance Cost |
| DMC | Drive Motor Assembly |
| DMCF | Deservicing |
| DME | Distance Measur Ng EquiPment |
| DME | Distance-measuring Equipment |
| DMG | Data Management Group |
| DMIA | Dual Multiplexer Interface Adapter |
| DMIS | Data Management Information System |
| DML | Developmental Instrumentation MDM-Left |
| DMON | Discrete Monitoring |
| DMP | Deployable Maintenance Platform |
| DMP | DEU Message Processor |
| DMP | Dump |
| DMR | Developmental Instrumentation MDM-Right |
| DMS | Data Management System |
| DMS | Docking Mechanism System (Subsystem) |
| DMS | Docking Module Subsystem |
| DMS | Dynamic Motion Simulator |
| DMSS | Data Management System Simulator (CVT) |
| DN | Discrepancy Notice |
| DN | Down |
| DNA | Does Not Apply |
| DNLK | Downlink (D/L Preferred) |
| DNLT | Downlist |
| DNO | Descending Node Orbit |
| DNP | Dynamic Nuclear Polarization |
| DO | Discrete Output |
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