| Acronym | Meaning |
 | DEDA | Data Entry And Display Assembly |
| DEE | Digital Events Evaluator |
| DEF | Definition |
| DEFL | Deflect |
| DEG | Degree |
| DEI | Design Engineering Identification |
| DEIS | Design Engineering Inspection Simulation |
| DEIS | Design Evaluation Inspection Simulator |
| DEL | Deliver |
| DEL | Deorbit |
| DELTA-T | Difference In Temperature |
| DEMOD | Demodulate |
| DEMUX | Demultiplexer |
| DEORB | Deorbit |
| DEPL | Deploy |
| DEPRESS | Depressurize |
| DEPT | Department |
| DER | Drawing Error Report |
| DERIGID | Derigidize |
| DES | Descend |
| DES | Data Exchange System |
| DESAT | Desaturated |
| DESC | Descent |
| DESIG | Designate |
| DESPOT | Design Performance OPtimization |
| DEST | Destination |
| DET | Detail |
| DET | Detent |
| DETN | Detection |
| DETR | Detector |
| DEU | Display Electronic(s) Unit |
| DEU | Display Electronics Unit |
| DEV | Develop |
| DEVN | Deviation |
| DEW | Distant Early Warning |
| DF | Development Flight |
| DF | Development-Forward |
| DF | Direction Finder (Finding) |
| DF | Disassembly Facility |
| DF | Display Functions |
| DF-SPE-A | Shuttle Project Engineering Office |
| DFCS | Digital Flight Control Software (System) |
| DFE | Data Flow Engineer |
| DFE | Direction Finding Equipment |
| DFG | Display Format Generator |
| DFI | Development Flight Instrumentation |
| DFI | Development Flight Instrumentation |
| DFR | Defrost |
| DFRC | Hugh L. Dryden Flight Research Center |
| DFRF | Dryden Flight Research Facility |
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