| Acronym | Meaning |
 | CSAM | Crinkled Single Aluminized Mylar |
| CSAS | ComPuterized Status Accounting System |
| CSAT | Combined Systems Acceptance Test |
| CSC | Computer Sciences Corporation |
| CSC | Conical Shaped Charge |
| CSC | Contingency SuPport Center (CCAFS) |
| CSC | Cosecant COMPuting Amplifier |
| CSCB | Contractor's Summary Cost Breakdown |
| CSCSAT | Commercial Synchronous Communication Satellite |
| CSD | Chemical Systems Division |
| CSD | Control System DeveloPment |
| CSD | Crew Systems Division |
| CSD | LCharles Stark Draper Laboratory (MIT) |
| CSDD | Control Systems DeveloPment Division (JSC) |
| CSDF | Central Source Data File |
| CSDT | COMPuter Software Data Tapes |
| CSE | Common Support EquiPment |
| CSE | Communications Systems Engineer |
| CSE | Computer Support Equipment |
| CSE | Configuration Switching EquiPment |
| CSF | Central Supply Facility |
| CSF | Cost Sensitivity Factor |
| CSI | Coelliptic Sequence Initiation |
| CSI | Control Servo Input |
| CSI | Crew Software Interface |
| CSIR | Computer Systems (Hardware/Software) Integration |
| CSIR | Review |
| CSIU | Core Segment Interface Unit |
| CSL | Command Signal Limiter |
| CSL | Computer Status Lights |
| CSL | Crew Systems Laboratory |
| CSM | Command Service Module |
| CSM | Common Support Module |
| CSM | Computer Status Matrix |
| CSOC | Consolidated Space Operations Center |
| CSOP | Crew Systems Operating Procedures |
| CSP | ComputerSupportProgram |
| CSPU | Coi-e Segment Processing Unit |
| CSR | Certification Status Report |
| CSR | Check Signal Return |
| CSR | Crew Station Review |
| CSR | Crew Station Review |
| CSRP | Computers And Software Review Panel |
| CSS | Computer Subsystem |
| CSS | Control Stick Steering |
| CSS | Control Stick Steering |
| CSS | Core Segment Simulator |
| CSSE | Control System Simulation Equipment |
| CST | Central Standard Time |
| CST | Combined Systems Test |
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