| Acronym | Meaning |
 | VLV | Valve |
| VM | Virtual Memory |
| VM | Voltmeter |
| VMF | Vertical Maintenance Facility |
| VMS | Velocity Measuring System |
| VO | Shuttle Operations (KSC Directorate) |
| VO | Space Vehicle Operations (KSC Dir.) |
| VO | Vehicle Operations |
| VO | Velocity Initial |
| VO | Voice |
| VOIR | Venus Orbiter Imaging Radar |
| VOL | Volume |
| VOM | Voltohmmeter |
| VOMD | VAFB Operations And Maintenance Documentation |
| VOR | VHF Omnidirectional Radio Range |
| VOR-DME | VHF Omni Range-UHF Distance Measuring Equipment |
| VORTAC | Variable Omni Range Tactical (VOR And TACAN) |
| VORTAC | VHF Omni Range Tactical Air Navigation |
| VOT | VHF Omni Test |
| VOX | Voice Operated Transmitter (Transmission) |
| VP | Shuttle Payloads (KSC VO Dir. |
| VP | Vacuum Pump |
| VP | Verification Polarization |
| VP | Vertical Polarization |
| VP | Viewpoint |
| VPF | Vertical Processing Facility |
| VPF | Vertical Processing Facility |
| VPHD | Vertical Payload Handling Device |
| VPI | Valve Position Indicator |
| VPK | Volts Peak |
| VPM | Vehicle ProjectManager |
| VR | Variable Reluctance |
| VR | Velocity Relative |
| VR | Video Recorder |
| VR | Voltage Regulator |
| VR | Voltage Relay |
| VRB | VHFRecoveryBeacon |
| VRCS | Vernier Reaction Control System |
| VREL | Relative Velocity |
| VRF | Vertical Removal Fixture |
| VRL | Vertical Recovery Line |
| VRL | Vertical Reference Line |
| VRMS | Volts Root MeanSquare |
| VRNR | Vernier |
| VRR | Verification Readiness Review |
| VS | Staging Velocity |
| VS | Versus |
| VSA | Variable Stability Aircraft |
| VSA | Verification Site Approval |
| VSB | Vestigial Side Band |
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