| Acronym | Meaning |
 | U/L | Uplink (UPLK Preferred) |
| U/M | Unit Of Measure |
| U/M | Unmanned |
| U/M | Unscheduled Maintenance |
| U/O | Used On |
| U/V | Under Voltage |
| U/W | Used With |
| UA | Microampere |
| UB | Upper Brace |
| UB | UpUtility Bridge |
| UBE | Universal Bus Exercisor |
| UBIC | Universal Bus Interface Controller |
| UC | Unsatisfactory Condition |
| UCC | Universal Checkout Console |
| UCD | Urine Collection Device |
| UCN | Uniform Control Number |
| UCPU | Urine Collection And Pretreatment Unit |
| UCR | Unsatisfactory Condition Report |
| UCS | Universal Control System |
| UCS | UnUtilities Control System |
| UCTA | Urine Collection Transfer Assembly |
| UD | Update |
| UDB | Update Buffer |
| UDF | Utility And Data Flow |
| UDL | Updata Link |
| UDL | Update Link |
| UDMH | Unsymmetrical Dimethylhydrazine |
| UDMH/H | Unsymmetrical Dimethylhydrazine Hydrazine Blend |
| UDOP | Ultrahigh Doppler |
| UDS | Universal Documentation System |
| UER | Unique Equipment Register |
| UF | Microfarad |
| UFD | User File Directory |
| UG | Microgram |
| UHF | Ultrahigh Frequency |
| UHF | Ultrahigh Frequency |
| UL | Underload |
| UL | Unit Of Issue |
| UL | Uplink |
| UL | Upper Left (S-Band Antenna) |
| UL | Upper Limit |
| UL | User Interface |
| ULA | Fairbanks |
| ULL | Ullage |
| ULO | Unmanned Launch Operations |
| ULT | Ultimate |
| UMB | Umbilical |
| UMBC | Umbilical Cord Cable |
| UMO | Unmanned Orbital |
| UMVF | Unmanned Vertical Flight |
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