| Acronym | Meaning |
 | TSB | Temporary Stowage Bag |
| TSB | Twin Sideband |
| TSC | Test Setup Complete |
| TSC | Test Support Coordinator |
| TSC | Two-Stage Command |
| TSCION | TSC 1/0 Number |
| TSCO | Test Support Coordination Office |
| TSCO | Test Support Coordinator |
| TSCP | Training Simulator Control Panel |
| TSD | Test Start Date |
| TSE | Transportation Support Equipment |
| TSGP | Test Sequence Generator Program (ESTEC) |
| TSLD | Troubleshooting Logic Diagram |
| TSM | Tail Service Mast |
| TSM | Tail Service Mast |
| TSM | Trade Study Management |
| TSO | Time Sharing Option |
| TSO | Time Since Overhaul |
| TSP | Test Software Program |
| TSP | Twisted Shielded Pairs (Cables) |
| TSR | Technical Status Review |
| TSR | Test Status Report |
| TSRA | Total System Requirements Analysis |
| TSS | Time Sharing System |
| TSS | TPS Summary Sheet Control |
| TSS | Tug Structural Support |
| TSSU | Test Signal Switching Unit |
| TST | Test |
| TSU | Time Standard Unit |
| TSW | Test Software |
| TSW | Test Switch |
| TT | Terminal Timing |
| TT | Thrust Termination |
| TT | Total Temperature |
| TT | Total Time |
| TT&C | Tracking |
| TT&C | Tracking Telemetry And Control |
| TTA | Thermomechanical Test Area |
| TTA | Time To Apogee |
| TTC | Telemetry |
| TTC | Time To Circularize (Orbit) |
| TTC | Tunnel Thermal Control |
| TTCA | Thrust Translation Controller Assembly |
| TTCV | Tracking Telemetry |
| TTE | Time To Event |
| TTE | LTool And Test Equipment List |
| TTG | Time To Go |
| TTL | Transistor-Transistor Logic |
| TTLM | Through-the-Lens Light Metering |
| TTP | Time To Perigee |
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