| Acronym | Meaning |
 | SL&I | System Load And Initialization |
| SL-SS | Spacelab Subsystems |
| SL-SSS | Spacelab Subsystem(s) Segment |
| SLA | ERNO Spacelab Product Assurance Department |
| SLA | Support And Logistics Areas |
| SLAC | Stanford Linear Accelerator Center |
| SLAHTS | Stowage List And Hardware Tracking System |
| SLAK | Spacelab Late Access Kit |
| SLAM | Side Load Arrest Mechanism |
| SLAR | Side Looking Airborne Radar |
| SLC | ERNO SPacelab Project Control |
| SLC | Space Launch Complex |
| SLCA | ERNO Spacelab Contract Administration |
| SLCC | ERNO Spacelab Configuration Management |
| SLCL | ShoP/Lab Configuration Layout |
| SLD | Stiff-Leg Derrick |
| SLE | ERNO Spacelab Engineering |
| SLEMU | SPacelab Engineering Model Unit |
| SLF | Shuttle Landing Facility (KSC) |
| SLF | Shuttle Landing Facility (OLF) |
| SLI | ERNO Spacelab Integration And Test |
| SLL | Shelf Life Limit |
| SLM | Sound Level Meter |
| SLN | ERNO SPacelab Payload |
| SLO | ERNO Spacelab Operations |
| SLOS | Star Line Of Sight |
| SLP | ERNO Spacelab Program Office |
| SLPB | Spacelab Program Board |
| SLRV | Shuttle Launched Research Vehicle |
| SLS | Secondary Landing Site |
| SLS | Sortie Lab Simulator |
| SLS | Spacelab Simulator |
| SLS | Spacelab Simulator |
| SLS | Statement Level Simulator |
| SLSA | Shuttle Logistics Support Aircraft |
| SLSMS | Spacelab Support Module Simulator |
| SLT | ERNO Spacelab Technology |
| SLV | Space Launch Vehicle |
| SM | Short Module |
| SM | Shuttle Management (KSC) |
| SM | SOft Manual |
| SM | Stable Member |
| SM | Support Module |
| SM | SYstems Management |
| SM | ESShuttle Mission Eng' |
| SM | ESShuttle Mission Evaluation Simulation (Simulator) |
| SM | IASerial Multiplexer Interface Adapter |
| SM&S | Systems Management And Sequencing |
| SM/PM | System Management/Performance Monitor |
| SMAB | Solid Motor Assembly Building |
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