| Acronym | Meaning |
 | SACS | SuPport Action Center |
| SACS | SYstems AllocationDocument |
| SACS | Systems Software Avionics Command SuPport |
| SADEC | SAEsociety Of Automotive Engineers |
| SADEC | SAEFspacecraft Assembly And EncaPsulation Facility |
| SADEC | SAES |
| SADEC | SAFESan Andreas Fault Experiment |
| SADEC | Spin Axis Declination |
| SADEC | Stand-Alone Engine Simulator |
| SAEF | Spacecraft Assembly And Encapsulation Facility (KSC) |
| SAG | E SAILShuttle Avionics Integration Laboratory |
| SAG | E Stratospheric Aerosol Gas Experiment |
| SAIL | Shuttle Avionics Integration Laboratory (JSC) |
| SAL | SALCSacramento Air Logistics Center |
| SAL | Scientific Airlock |
| SAL | Shuttle Avionics Laboratory |
| SAM | SAMPShuttle Automated Mass Properties |
| SAM | SAMSShuttle Attachment ManiPulator SYstem |
| SAM | Shuttle Attachment ManiPulator |
| SAM | SYstem Activation And Monitoring |
| SAMSO | Space And Missile SYstems Organization (USAF) |
| SAMSOR | SAMSO Regulation (now SDR) |
| SAMTEC | SPace And Missile Test Center (VAF CA) |
| SAMTEC | Space And Missile Test Center Manual |
| SAMTO | Space And Missi E Test Organization (VAFE3) |
| SAND | I |
| SAP | Site Activation Need Date |
| SAR | SafetY AnalYsis Report |
| SAR | Search And Rescue |
| SAR | Strain Arrestor Plate |
| SARP | SafetY AnalYsis RePort For Packaging |
| SARP | Summary AnalYsis Report |
| SART | Shuttle Astronaut Recruitment Program |
| SAS | Solar Array SYstem |
| SAS | StabilitY Augmentation SubsYstem |
| SAS | StabilitY Augmented SYstem |
| SAS | Stimuli Analog Refresh Table |
| SASTP | Stand-Alone Self-Test Program |
| SAT | Saturate |
| SAT | Systems Approach To Training |
| SATAF | Shuttle Activation Task Force |
| SATO | Shuttle Attached Teleoperator |
| SATO | Supply And Transportation Operations |
| SATS | Shuttle Avionics Test System |
| SATS | Small Applications Technology Satellite |
| SAU | Signal Acquisition Unit |
| SAU | StraP Around Unit |
| SAVER | Shuttle Avionics Verification And Evaluation |
| SAWD | Solid Amine Water Desorbed |
| SB | Space Base |
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