| Acronym | Meaning |
 | S/C | Stripchart (Recorder) |
| S/C | Subcontractor |
| S/EOS | Standard Earth Observation Satellite |
| S/F | Safety Factor |
| S/F | Single Flow |
| S/G | Strain Gage |
| S/L | Shop/Laboratory |
| S/M | Scheduled Maintenance |
| S/M | Service/Maintenance |
| S/M | Structural/Mechanical |
| S/M | Systems Management |
| S/N | Serial Number |
| S/N | Signal-to-Noise Ratio |
| S/P | Serial To Parallel |
| S/P | Signal Processor |
| S/R | Send And Receive |
| S/R | Shift Register |
| S/R | Stimulus/Response |
| S/S | Samples Per Second |
| S/S | Single Sideband |
| S/S | Space Shuttle |
| S/S | Subsystem |
| S/SYS | Subsystem |
| S/U | Set Up |
| S/V | Space Vehicle |
| S/V | SuPply Valve |
| S/W | Software |
| S@MSCC | Shuttle Mission Simulator Computer Complex |
| S@MSCC | SYstem |
| SA | Safing Area |
| SA | Shaft Angle |
| SA | Single Access |
| SA | Site Activation |
| SA | Subaccount |
| SA | Supplemental Agreement |
| SA | Support Area |
| SAA | Safety Assurance Analysis |
| SAA | South Atlantic Anomaly |
| SAAC | Schedule Allocation And Control |
| SAALC | San Antonio Air Logistics Center |
| SAAM | Special Air Force Airlift Mission |
| SAAMA | San Antonio Air Material Area |
| SAAS | Shuttle Aerosurface Actuator Simulation |
| SAB | SACstrategic Air Command(USAF) |
| SAB | Shuttle Avionics Breadboard |
| SAB | Spacecraft Assembly Building |
| SAB | Storage And Assembly Building |
| SACS | SADshuttle AuthorizedDocument |
| SACS | Software Avionics Command SuPport |
| SACS | Spacecraft Attitude Display |
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