| Acronym | Meaning |
 | CL | Close (Closed) |
| CL | Closed Loop |
| CL | Closed Loop Contro! Logic |
| CL | Cluster |
| CL | Coefficient Of Lift |
| CLASS | Classification |
| CLC | Change Letter Control |
| CLDST | Closed Loop Dynamic Stability Test |
| CLG | Ceiling |
| CLIP | Combined Laser Instrumentation Package |
| CLM | Care Logic Module |
| CLMC | Central Logistics Management Center |
| CLNR | Cleaner |
| CLR | Clear |
| CLRB | Cost Limit Review Board |
| CLS | Contingency Landing Site(s) |
| CLSO | Contingency Landing Support Officer |
| CLT | Closed Loop Test |
| CM | Cargo Management |
| CM | Center Of Mass |
| CM | Centimeter |
| CM | Configuration Management |
| CM | Consumables Management |
| CM | Control Monitor |
| CM | Crew Module |
| CM&S | Communications Maintenance And Storage |
| CMA | Configuration Management Accounting |
| CMACS | Central Monitor And Control System |
| CMAO | Contract Management Assistance Officer |
| CMAT | Compatible Materials (List) |
| CMC | Command Module Computer |
| CMC | Crew Module Computer |
| CMD | Command |
| CMD | DCDR Command Decoder |
| CMG | Control Moment Gyro |
| CMM | Condition Monitored Maintenance |
| CMN | Crewman |
| CMO | Configuration Management Office |
| CMOS | Complementary Metal Oxide Silicon |
| CMP | Configuration Management Plan |
| CMPR | Compare |
| CMPRT | Compartment |
| CMPTD | Computed |
| CMPTR | Computer |
| CMPTR | ACTYComputer Activity |
| CMR | Center Materials Representative |
| CMRB | Contractor Material Review Board |
| CMRR | Common Mode Rejection Ratio |
| CMS-2 | Cambridge Monitoring System (IBM Computer Program) |
| CMSI | Checkout/Control And Monitor Subsystem Interface |
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