| Acronym | Meaning |
 | SVC | Switched Virtual Circuit |
| SVG | Scalable Vector Graphics |
| SVGA | Super Video Graphics Array |
| SWISH | Simple Web Indexing System For Humans |
| SYN | Synchronize Sequence Number |
| SYSOP | System Operator |
| T1 | T-One - Carrier Signal (communications) |
| T3 | T-Three - Carrier Signal (communications) |
| TA | Terminal Adapter |
| TANSTAAFL | There Ain't No Such Thing As A Free Lunch |
| TAPI | Telephony Application Programming Interface |
| TCP/IP | Transmission / Transport Control Protocol/Internet Protocol |
| TDM | Time Division Multiplexing |
| TDMA | Time Division Multiple Access |
| TFT | Thin Film Transistor |
| TFTP | Trivial File Transfer Protocol |
| TIA | Thanks In Advance |
| TIFF | Tagged Image File Format |
| TIGA | Texas Instruments Graphics Architecture |
| TLD | Top-Level Domain |
| TOPS | Transparent Operating System |
| TPI | Tracks Per Inch |
| TRAM | Transactional RAM |
| TSAPI | Telephony Service API |
| TSR | Terminate-and-Stay-Resident |
| TTF | True Type Font |
| TTL | Transistor-Transistor Logic |
| TWAIN | Technology Without An Interesting Name |
| TWIP | Twentieth Of A Point |
| UAC | User Account Control |
| UART | Universal Asynchronous Receiver/Transmitter |
| UCITA | Uniform Computer Information Transaction Act |
| UDDI | Universal Description, Discovery And Integration |
| UDP | UDP - User Datagram Protocol |
| UIN | Universal Internet Number |
| ULSI | Ultra Large Scale Integration |
| ULTRAATA | Ultra AT Attachment |
| ULTRADMA | Ultra Direct Memory Access |
| UMB | Upper Memory Block |
| UML | Unified Modeling Language |
| UNC | Universal Naming Convention |
| UNIX | Universal Interactive Executive / Uniplexed Information And Computing System |
| UPS | Uninterruptible Power Supply |
| URI | Uniform Resource Indicator |
| URL | Uniform Resource Locator |
| USB | Universal Serial Bus |
| USENET | User Network |
| USR | US Robotics |
| UTP | Unshielded Twisted Pair |
| UUCP | UNIX-to-UNIX Copy |
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