| Acronym | Meaning |
 | SCCCAMP | South Central Coast Cooperative Aerometric Monitoring Program |
| SCCM | Single-column CCM |
| SCD | Scientific Computing Division |
| SCDUG | Scientific Computing Division Users Group Scelming |
| SCEP | Study Of Critical Environmental Problems |
| SCF | Standard Cubic Feet |
| SCGB | Special Committee For The Geosphere-Biosphere |
| SCM | Stratospheric Circulation Model |
| SCM | Small Core Memory |
| SCM | Solar Constant Monitor |
| SCMS | Software Configuration Management Section |
| SCO | Subcarrier Oscillators |
| SCOPE | Scientific Committee On Problems Of The Environment |
| SCOR | Scientific Committee For Oceanographic Research |
| SCOSTEP | Scientific Committee On Solar-Terrestrial Physics |
| SCPP | Sierra Cooperative Pilot Project |
| SCR | Selective Chopper Radiometer |
| SCR | Silicon Controlled Rectifier |
| SCS | Soil Conservation Service |
| SCSC | Summer Computer Simulation Conferences |
| SCSI | Small Computer System Interface |
| SCST | State Committee On Science & Technology |
| SCST | State Committee On Science & Technology |
| SD | Standard Deviation |
| SDAM | Satellite Data Access And Management Format |
| SDBE | Shear-Directed Balloon Experiment |
| SDD | Systems Development Division |
| SDF | Shared Data Facility |
| SDHS | Satellite Data Handling System |
| SDM | Suit Of Software For UNIX-based Computing Platforms |
| SDM | Scientific Data Management |
| SDS | Solar Disk Sextant |
| SDS | Scientific Data Systems |
| SDSC | San Diego Supercomputing Center |
| SDSD | Satellite Data Services Division |
| SDSMT | South Dakota School Of Mines & Technology |
| SDVR | Single-Doppler Velocity Retrieval |
| SEAB | Secretary Of Energy Advisory Board |
| SEAC | (National Bureau Of) Standards Eastern Automatic Computer |
| SEAD | Secretary Of Energy Advisory Board |
| SEASAT | Sea Satellite |
| SEAWIFS | Sea Wide-Field Sensor |
| SEC | Securities & Exchange Commission |
| SEC | Science Executive Committee |
| SEDI | Structure Of The Earth's Deep Interior |
| SEDI | Structure Of The Earth's Deep Interior |
| SEE | Solar EUV Experiment |
| SEL | Space Environment Laboratory |
| SEM | Scanning Electron Microscope |
| SEM | Space Environment Monitor |
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