| Acronym | Meaning |
 | IRAC | Interdepartmental Radio Advisory Committee |
| IRAS | Infrared Astronomical Satellite |
| IRC | International Research Council |
| IRC | International Radiation Commission |
| IRCAT | Infrared Radiometer To Detect (CAT) Horizontal Temperature Gradients |
| IRCTR | International Research Centre For Telecommunication-transmission And RADAR |
| IRD | Instrument Requirement Document |
| IRD | Interface Requirements Document |
| IRE | Institute Of Radio Engineers |
| IRH | Infrared Hygrometer |
| IRI | Interagency Research Internet |
| IRI | International Research Institute For Climate Prediction |
| IRICP | International Research Center For Climate Prediction |
| IRIG | Inertial Rate (MIT) Or Reference (NASA) Integrating Gyroscope |
| IRIG | Inter-range Instrumentation Group |
| IRIS | Infrared Interferometer Spectrometer |
| IRIS | Incorporated Research Institutions For Seismology |
| IRIS | Italian Research Interim Stage |
| IRJE | Internet Remote Job Entry |
| IRLS | Interrogation & Reading Location System |
| IRMS | Isotope Ratio Mass Spectrometer |
| IRR | Integrated Requirements Review |
| IRS | Indian Remote-sensing Satellite |
| IRS | Information Retrieval Service |
| IS | Institute Sponsors |
| ISA | Instrument Society Of America |
| ISAMS | Improved Stratospheric And Mesospheric Sounder |
| ISAS | Institute Of Space And Astronautical Science |
| ISBN | International Standard Book Number |
| ISCAT | Investigation Of Sulfur Chemistry In Antarctic Troposphere |
| ISCCP | International Satellite Cloud Climatology Program |
| ISDN | Integrated Services Digital Network |
| ISF | In-Situ Sensing Facility |
| ISF | International Symposium On Forecasting |
| ISFF | Integrated Surface Flux Facilities |
| ISG | Immersion Sensing Group |
| ISIS | International Satellites For Ionospheric Studies |
| ISLSCP | International Satellite Land-Surface Climatology Project |
| ISM | In Situ Measurements |
| ISMG | International Scientific And Management Group |
| ISMP | In-Situ Measurements Project |
| ISMRM | Integrated Soil Moisture Retrieval Models |
| ISNAR | International Service For National Agricultural Research |
| ISO | International Standards Organization |
| ISOC | Integrated Science Operations Center |
| ISOS | International Southern Ocean Study |
| ISP | Internet Service Provider |
| ISPAN | Information Stream Project For AWIPS NOAAport |
| ISPRA | N/A |
| ISR | Individual Schedule Request |
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